Metabolically healthy obesity or metabolism-healthy obesity ( MHO ) is a debatable medical condition characterized by obesity that does not produce metabolic complications.
Video Metabolically healthy obesity
Characteristics
There are no universally accepted criteria available to determine the alleged MHO, but the general definition requires patients to be obese and lack of metabolic abnormalities such as dyslipidemia, impaired glucose tolerance, or metabolic syndrome.
Individual MHOs exhibit less visceral adipose tissue, smaller adipocytes, and reduced inflammatory profiles relative to individuals with metabolic unhealthy obesity. Their cardiometabolic risk did not increase significantly as a result of weight-loss intervention.
Maps Metabolically healthy obesity
Epidemiology
Estimates of MHO prevalence vary from 6 to 75 percent, and it has been argued that between 10 and 25 percent of healthy, metabolically healthy individuals. One study found that 47.9% of obese people had MHO, while others found that 11% did so. It seems to be more common in women than men, and its prevalence decreases with age.
Results
Several studies have shown that individuals with metabolically healthy obesity are at increased risk for some adverse outcomes, including type 2 diabetes, depressive symptoms, and cardiovascular events. Other studies have also shown that although the MHO individual displays a favorable metabolic profile, this does not imply a reduction in mortality. Research to date has yielded conflicting results with respect to cardiovascular disease and mortality. Individual MHOs have a higher risk of cardiovascular disease compared to unhealthy individuals who are metabolically healthy, but they are also at lower risk than unhealthy and obese individuals. A 2016 meta-analysis found that MHO individuals did not experience an increased risk of all-cause mortality (but at an increased risk of cardiovascular events). The relatively low risk of cardiovascular disease among people with MHO relative to people with metabolic unhealthy obesity has been associated with differences in white adipose tissue function between the two groups.
References
Source of the article : Wikipedia
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